IsoaMyl 4-MethoxycinnaMate
Synonym(s):Amiloxate;Isoamyl p-methoxycinnamate;Isoamyl 4-methoxycinnamate;Isopentyl 4-methoxycinnamate;4-Methoxycinnamic acid 3-methylbutyl ester
- CAS NO.：71617-10-2
- Empirical Formula: C15H20O3
- Molecular Weight: 248.32
- MDL number: MFCD00583856
- EINECS: 275-702-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-17 09:49:53
What is IsoaMyl 4-MethoxycinnaMate?
Absorption
According to in vitro studies of amiloxate-containing tape strips on porcine ear, there was no detection of amiloxate undergoing skin penetration .
Toxicity
Oral LD50 in rat is 9600 mg/kg .
Chemical properties
Light yellow viscous liquid
The Uses of IsoaMyl 4-MethoxycinnaMate
Isoamyl 4-Methoxycinnamate is used in the highly protective sunscreen composition against the UVA/UVB.
Indications
Indicated as an active sunscreen agent.
Background
Amiloxate is an EMA-approved chemical UV-filter found in over-the-counter sunscreen products at concentrations up to 10%m . It is often referred to as isoamyl 4-methoxycinnamate or isoamyl p-methoxycinnamate. Amiloxate is a cinnamic acid derivative with an anti-inflammatory activity .
Definition
ChEBI: Amiloxate is a cinnamate ester.
brand name
Neo Heliopan (H & R Florasynth) [Namepreviously used: Isoamyl Methoxycinnamate.] [Note—The International Cosmetic Ingredient (INCI) name for amiloxate is isoamyl p-methoxycinnamate.].
Pharmacokinetics
In a mouse study, amiloxate exerted a dose-dependent anti-inflammatory action and inhibited edema by about 70% even at a low dose . Due to structural similarities, amiloxate may also display antioxidant and antimicrobial properties of cinnamic acid .
Metabolism
No pharmacokinetic data available.
Properties of IsoaMyl 4-MethoxycinnaMate
| Boiling point: | 158°C/0.7mmHg(lit.) |
| Density | 1.04 |
| vapor pressure | 0.007Pa at 25℃ |
| refractive index | 1.5560 to 1.5600 |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Liquid |
| form | neat |
| color | Light yellow to Yellow to Orange |
| Water Solubility | 2.47mg/L at 20℃ |
| BRN | 3132627 |
Safety information for IsoaMyl 4-MethoxycinnaMate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H413:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. |
Computed Descriptors for IsoaMyl 4-MethoxycinnaMate
New Products
Indole Methyl Resin tert-butyl 9-methoxy-3-azaspiro[5.5]undecane-3-carboxylate Boc-His(Boc)-OH 2-CTC Resin 4-Chloro-7-tosy1-7Hpyrrolo[2,3-d]pyrimidine 5,7-Dibromo-1H-indole 2,5-dichloro-N-hydroxy-4,6-dimethylpyridine-3-carboximidamide 2,2-Dimethoxy-7-azaspiro[3.5]nonane hydrochloride 4-chloromethyl-5-methyl-1,3-dioxol-2-one (DMDO-Cl) R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDIIMIDAZOLE 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) N-METHYL INDAZOLE-3-CARBOXYLIC ACID 4-((2-hydroxyethyl)thio)benzoic acid 1-(TERT-BUTOXYCARBONYL)-2-PYRROLIDINONE Methyl 6-methylnicotinate 3-Pyridineacrylic acid tert-Butyl carbazate TETRAHYDRO-2H-PYRAN-3-OL 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile 2,4-dihydroxybenzaldehyde 1,3-Diethyl-1,3-Diphenylurea Methyl 2-methylquinoline-6-carboxylateRelated products of tetrahydrofuran
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