Iodomethyl pivalate

Chemical properties

Pale Yellow Liquid

The Uses of Iodomethyl pivalate

Iodomethyl pivalate can be used as reagent used for the addition of pivaloyl group.

What are the applications of Application

Iodomethyl Pivalate is a reagent used for the addition of pivaloyl group

Synthesis Reference(s)

The Journal of Organic Chemistry, 48, p. 5280, 1983 DOI: 10.1021/jo00174a024

Synthesis

Iodomethyl pivalate is synthesised using chloromethyl pivalate as a raw material by chemical reaction. The specific synthesis steps are as follows:
Three bottles were added 10.0 g of chloromethyl pivalate, Ethyl acetate 30 mL, 11.6 g of sodium iodide and 3.6 g of calcium chloride, After heating to 78 ° C for 6 h, Cooling to 0 ,Then washed with 5% sodium thiosulfate to colorless, Dried over anhydrous magnesium sulfate, Concentrated under reduced pressure. 16 g of a yellow liquid. Iodomethyl pivalate was obtained. The reaction molar yield was 94% and GC: 98%.