inh-02 (RNF5 inhibitor inh-02)
- CAS NO.：324579-65-9
- Empirical Formula: C23H20N4S
- Molecular Weight: 384.5
- MDL number: MFCD01849637
- Update Date: 2026-07-24 20:02:54
What is inh-02 (RNF5 inhibitor inh-02)?
Biological Activity
RNF5 inhibitor inh-02 is a potent inhibitor of E3 ubiquitin ligase RNF5/RMA1. RNF5 inhibitor inh-02 leads to significant F508del-CFTR rescue (EC50=2.2 uM) in bronchial epithelial cells homozygous for the F508del mutation. RNF5 inhibitor inh-02 can be used for cystic fibrosis research[1].
References
[1]. Elvira Sondo, et al. Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia. Cell Chem Biol. 2018 Jul 19;25(7):891-905.e8.
Properties of inh-02 (RNF5 inhibitor inh-02)
| form | Solid |
| color | White to yellow |
Safety information for inh-02 (RNF5 inhibitor inh-02)
Computed Descriptors for inh-02 (RNF5 inhibitor inh-02)
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