INF39

Synonym(s):2-Chloro-α-methylene-benzenepropanoic acid ethyl ester;Ethyl 2-(2-chlorobenzyl)acrylate

CAS NO.：866028-26-4
Empirical Formula: C12H13ClO2
Molecular Weight: 224.68
MDL number: MFCD27930542
Update Date: 2026-01-16 16:10:54

What is INF39?

The Uses of INF39

INF 39 is a NLRP3 inflammasome inhibitor. Used in the treatment of inflammatory bowel disease.

Biochem/physiol Actions

INF39 is an orally active acrylate derivative and a non-cytotoxic INF4E analog (no toxicity at 100 μM in THP-1 cultures vs. TC50 = 65 μM with INF4E) that acts as an irreversible inhibitor against NLRP3 (NACHT, LRR and PYD domains-containing protein 3) ATPase activity (52% inhibition in 15 min by 100 μM INF39; 105 ng human NLP3 & 250 μM ATP) essential for the NLRP3 inflammasome assembly and activation. INF39 effectively decreases 5 mM (30 min) ATP-induced interleukin-1β (IL-1β) release and pyroptosis of murine bone marrow-derived macrophages in cultures (by 55-58% and 43-65%, respectively, with 1-hr 10 μM INF39 pretreatment of LPS-primed BMDM) and alleviates gut-associated inflammation in a rat model of 2,4-dinitrobenzenesulfonic acid (DNBS)-induced colitis in vivo (12.5-50 mg/kg/day in 0.2 mL olive oil p.o.).

Storage

Store at -20°C

Properties of INF39

Boiling point:	309.3±30.0 °C(Predicted)
Density	1.131±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO:66.0(Max Conc. mg/mL);293.75(Max Conc. mM) Ethanol:30.0(Max Conc. mg/mL);133.52(Max Conc. mM)
form	oil
color	colorless to light brown

Safety information for INF39

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for INF39

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