Prostaglandin J2-d4

Description

Prostaglandin J₂-d₄ is intended for use as an internal standard for the quantification of prostaglandin J₂ by GC- or LC-MS. Prostaglandin J₂ (PGJ₂) is formed from PGD₂ by the elimination of the C-9 hydroxyl group, a process which is accelerated by the presence of albumin.¹ PGJ₂ inhibits platelet aggregation with an IC₅₀ of about 5-10 nM.^2,3 PGJ₂ has antimitotic and antiproliferative effects on a variety of cultured normal cells and tumor cell lines.⁴ However, this activity has been attributed to further metabolites of PGJ₂ and not the parent compound itself.

References

1. Fitzpatrick, F.A., and Wynalda, M.A. Albumin-catalyzed metabolism of prostaglandin D₂. Identification of products formed in vitro J. Biol. Chem. 258(19),11713-11718(1983).
2. Bundy, G.L., Morton, D.R., Peterson, D.C., et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues J. Med. Chem. 26(6),790-799(1983).
3. Mahmud, I., Smith, D.L., Whyte, M.A., et al. On the identification and biological properties of prostaglandin J₂ Prostaglandins Leukot. Med. 16(2),131-146(1984).
4. Fukushima, M. Prostaglandin J₂ - anti-tumor and anti-viral activities and the mechanisms involved Eicosanoids 3(4),189-199(1990).