Adenosine, N,N′′-(2E)-2-butene-1,4-diyl-[P(R)]-2′-deoxy-2′-fluoro-5′-O-[(S)-hydroxymercaptophosphinyl]-P-thioadenylyl-(3′→5′)-2′-deoxy-2′-fluoro-, cyclic nucleotide, ammonium salt (1:2)

CAS NO.：2242635-03-4
Empirical Formula: C24H29F2N11O8P2S2
Molecular Weight: 763.63
Update Date: 2026-04-24 14:58:30

What is Adenosine, N,N′′-(2E)-2-butene-1,4-diyl-[P(R)]-2′-deoxy-2′-fluoro-5′-O-[(S)-hydroxymercaptophosphinyl]-P-thioadenylyl-(3′→5′)-2′-deoxy-2′-fluoro-, cyclic nucleotide, ammonium salt (1:2)?

Biological Activity

E7766 diammonium salt is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities[1]. E7766 diammonium salt inhibits four human STING variants, human wild-type, HAQ, AQ and REF STING proteins, with EC50 values of 1 μM, 2.2 μM, 1.2 μM and 4.9 μM, respectively[1]. In murine colon cancer model, a single intratumoral injection of 10 mg/kg E7766 diammonium salt in the subcutaneous tumor. E7766 diammonium salt is shown to have potent antitumor activity with long lasting immune memory response in a mouse liver metastatic tumor model[1].

References

[1]. Dae-Shik Kim, et al. E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity. ChemMedChem. 2021 Jun 7;16(11):1740-1743.

Properties of Adenosine, N,N′′-(2E)-2-butene-1,4-diyl-[P(R)]-2′-deoxy-2′-fluoro-5′-O-[(S)-hydroxymercaptophosphinyl]-P-thioadenylyl-(3′→5′)-2′-deoxy-2′-fluoro-, cyclic nucleotide, ammonium salt (1:2)

storage temp.	Store at -20°C
form	Solid
color	White to off-white

Safety information for Adenosine, N,N′′-(2E)-2-butene-1,4-diyl-[P(R)]-2′-deoxy-2′-fluoro-5′-O-[(S)-hydroxymercaptophosphinyl]-P-thioadenylyl-(3′→5′)-2′-deoxy-2′-fluoro-, cyclic nucleotide, ammonium salt (1:2)

Computed Descriptors for Adenosine, N,N′′-(2E)-2-butene-1,4-diyl-[P(R)]-2′-deoxy-2′-fluoro-5′-O-[(S)-hydroxymercaptophosphinyl]-P-thioadenylyl-(3′→5′)-2′-deoxy-2′-fluoro-, cyclic nucleotide, ammonium salt (1:2)

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