(1-(5-fluoro-4-hydroxypentyl)-1H-indol-3-yl-2,4,5,6,7-d5)(naphthalen-1-yl)methanone

Description

AM2201 N-(4-hydroxypentyl) metabolite-d₅ contains five deuterium atoms at the 2, 4, 5, 6, and 7 positions. It is intended for use as an internal standard for the quantification of AM2201 N-(4-hydroxypentyl) metabolite by GC- or LC-mass spectrometry. AM2201 is a potent synthetic cannabinoid (CB) with K_i values of 1.0 and 2.6 nM for the CB₁ and CB₂ receptors, respectively.¹ AM2201 N-(4-hydroxypentyl) metabolite is an expected urinary metabolite of AM2201, based on the known metabolism of similar compounds.² Its biological actions are unknown.

References

1. Makriyannis, A., and Deng, H. Cannabimimetic indole derivatives US7241799B2,(2001).
2. Wintermeyer, A., M?ller, I., Thevis, M., et al. In vitro phase I metabolism of the synthetic cannabimimetic JWH-018 Anal. Bioanal. Chem. 398(5),2141-2153(2010).