PAR2 (1-6) amide (human) (trifluoroacetate salt)

CAS NO.：2379569-17-0
Empirical Formula: C30H55F3N8O9
Molecular Weight: 728.81
Update Date: 2026-01-05 11:31:08

What is PAR2 (1-6) amide (human) (trifluoroacetate salt)?

Biological Activity

PAR2 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR2 and residues 37-42 of the full-length sequence.1 It binds to NCTC 2544 cells expressing human PAR2 (Ki = 9.64 μM in a radioligand binding assay) and induces calcium mobilization in the same cells (EC50 = 0.075 μM).2 PAR2 (1-6) amide (100 μM) reduces colony formation of A549 lung cancer cells.1 It induces superoxide production and degranulation in isolated human eosinophils when used at a concentration of 500 μM.3 PAR2 (1-6) amide (5 μmol/kg) induces tear secretion in rats when used in combination with amastatin .4

References

1.Bohm, S.K., Kong, W., Bromme, D., et al.Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2Biochem. J.314(Pt 3)1009-1016(1996) 2.Kanke, T., Ishiwata, H., Kabeya, M., et al.Binding of a highly potent protease-activated receptor-2 (PAR2) activating peptide, [3H]2-furoyl-LIGRL-NH2, to human PAR2Br. J. Pharmacol.145(2)255-263(2005) 3.Miike, S., McWilliam, A.S., and Kita, H.Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2J. Immunol.167(11)6615-6622(2001) 4.Nishikawa, H., Kawai, K., Tanaka, M., et al.Protease-activated receptor-2 (PAR-2)-related peptides induce tear secretion in rats: Involvement of PAR-2 and non-PAR-2 mechanismsJ. Pharmacol. Exp. Ther.312(2)324-331(2005)

Properties of PAR2 (1-6) amide (human) (trifluoroacetate salt)

storage temp.	-20°C
solubility	DMF: 30 mg/ml,DMSO: 15 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 10 mg/ml
form	A solid

Safety information for PAR2 (1-6) amide (human) (trifluoroacetate salt)

Computed Descriptors for PAR2 (1-6) amide (human) (trifluoroacetate salt)

New Products

Paroxetine Impurity G/Paroxetine Related Compound E 1-Aminocyclopentane carbonitrile (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid N,N CARBONYL DIIMIDAZOLE 2-Amino-5-bromo-4-(trifluoromethyl)pyridine（RM for Indian lab) Benzyl (3R,4S)-3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate (R)-1-Benzyl-3-pyrrolidinecarbonitrile Betahistine EP Impurity C Cyclobenzaprine N-oxide/Citalopram Related Compound E Chlorthalidone Impurity I Carbamazepine EP Impurity G Sumatriptan Succinate USP Related Compound C 2,2'-(5-methyl-1,3-phenylene)-di(2-Methylpropionitrile) 4-Fluorothiophenol 1-methyl amino-2,4-dinitro benzene 5-Methyl-1,3-benzenediacetonitrile (R)-BoroLeu-(+)-Pinanediol-CF3COOH 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. 4-Bromo Benzylcyanide 3-Hydroxypropionitrile 3,4 Dimethoxy Benzylcyanide valeronitrile 3-chlorobenzyl cyanide 2-Chloro Benzylcyanide