CAM833

CAS NO.：2758364-02-0
Empirical Formula: C26H26ClFN4O5
Molecular Weight: 528.96
Update Date: 2026-05-11 19:39:08

What is CAM833?

Description

CAM833 is a potent orthosteric inhibitor of the interaction between BRCA2 and RAD51 with a K_d of 366 nM against the ChimRAD51 protein. CAM833 also inhibits RAD51 oligomerization^[1].

CAM833 (3.125-50 μM; 24 h) causes a concentration-dependent decrease in RAD51 foci and subsequent increase in DNA damage^[1].
CAM833 (25 μM) inhibits RAD51 molecular clustering at DNA damage sites^[1].
CAM833 (0-50 μM) inhibits DNA repair by homologous recombination^[1].
CAM833 (20 μM; 0-72 h) potentiates radiation-induced cell-cycle arrest and increases apoptosis over time^[1].
CAM833 (10 μM) causes a dose-dependent growth inhibition that is enhanced when combined with ionizing radiation^[1].
CAM833 (20 μM; 96 h) potentiates the growth suppressive effect of PARP1 inhibition in BRCA2 wild-type cells^[1].

Cell Cycle Analysis^[1]

Storage

Store at -20°C

Properties of CAM833

Boiling point:	868.2±65.0 °C(Predicted)
Density	1.398±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble to 100 mM in DMSO and to 5 mM in ethanol
form	Solid
pka	11.12±0.46(Predicted)
color	White to off-white

Safety information for CAM833

Computed Descriptors for CAM833

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