tert-butyl N-[(2S)-1-[(2S,4R)-4-({[2-(methanesulfonylsulfanyl)-2-methylpropoxy]carbonyl}oxy)-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate

CAS NO.：2417370-08-0
Empirical Formula: C33H48N4O9S3
Molecular Weight: 740.96
Update Date: 2026-01-13 11:17:34

What is tert-butyl N-[(2S)-1-[(2S,4R)-4-({[2-(methanesulfonylsulfanyl)-2-methylpropoxy]carbonyl}oxy)-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate?

Description

ARN70080 is a ProTAC building block. ARN70080 contains a von Hippel--Lindau (VHL)-rectuiting ligand and a pendant disulfide, linked via a carbonate group. The pendant disulfide allows for targeted degradation of antibodies. This product has no formal name at the moment.

Properties of tert-butyl N-[(2S)-1-[(2S,4R)-4-({[2-(methanesulfonylsulfanyl)-2-methylpropoxy]carbonyl}oxy)-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate

Boiling point:	924.1±65.0 °C(Predicted)
Density	1.31±0.1 g/cm3(Predicted)
pka	11.57±0.46(Predicted)

Safety information for tert-butyl N-[(2S)-1-[(2S,4R)-4-({[2-(methanesulfonylsulfanyl)-2-methylpropoxy]carbonyl}oxy)-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate

Computed Descriptors for tert-butyl N-[(2S)-1-[(2S,4R)-4-({[2-(methanesulfonylsulfanyl)-2-methylpropoxy]carbonyl}oxy)-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate

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