Mal-(CH2)5-Val-Cit-PAB-Eribulin

CAS NO.：2130869-21-3
Empirical Formula: C69H97N7O19
Molecular Weight: 1328.55
Update Date: 2025-04-17 18:22:24

What is Mal-(CH2)5-Val-Cit-PAB-Eribulin?

Biological Activity

Mal-(CH2)5-Val-Cit-PAB-Eribulin is a drug-linker conjugate for ADC with potent antitumor activity by using the anti-microtubule agent, Eribulin, linked via linker Mal-(CH2)5-Val-Cit-PAB[1]. Eribulin (E7389) is a microtubule targeting agent that is used for the research of metastatic breast cancer. Eribulin inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules[2].

References

[1]. Earl F Albone, et al. Eribulin-based antibody-drug conjugates and methods of use. Patent US20170252458A1. [2]. Watanabe K, et, al. Low-dose eribulin reduces lung metastasis of osteosarcoma in vitro and in vivo. Oncotarget. 2019 Jan 4; 10(2): 161-174.

Properties of Mal-(CH2)5-Val-Cit-PAB-Eribulin

Density	1.34±0.1 g/cm3(Predicted)
pka	11.93±0.46(Predicted)
form	Solid
color	White to yellow

Safety information for Mal-(CH2)5-Val-Cit-PAB-Eribulin

Computed Descriptors for Mal-(CH2)5-Val-Cit-PAB-Eribulin

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