INCB-047775

CAS NO.：1430056-54-4
Empirical Formula: C22H20FN5O
Molecular Weight: 389.43
MDL number: MFCD30470660
Update Date: 2025-10-29 15:43:00

What is INCB-047775?

Biological Activity

AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s < 500nM, respectively. (patent WO2013056015A1). Akt is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer[2].

References

[1]. Taisheng Huang; et al.Isoindolinone and pyrrolopyridinone derivatives as akt inhibitors. WO2013056015A1. [2]. Manning BD, et al. AKT/PKB signaling: navigating downstream. Cell. 2007;129(7):1261-1274.

Properties of INCB-047775

storage temp.	Store at -20°C
solubility	DMSO : 125 mg/mL (320.98 mM; Need ultrasonic)
form	Solid
color	Yellow to brown

Safety information for INCB-047775

Computed Descriptors for INCB-047775

New Products

Dexamethasone Sodium Phosphate 2-(2-Ethoxyphenoxy)ethyl bromide 8-Bromo-7-(2-butynyl)-3-methyl xanthine 5-Chlorothiophene-2-carboxylic acid m-Tolualdehyde p-Anisaldehyde 2-Bromobenzaldehyde 4-Fluorobenzaldehyde 1-Propyl-4-piperidone 3-Amino-3-(3-fluorophenyl)propanoic acid 2-Fluoro-6-iodobenzoic acid 3-(4-Bromo-3-methyl-2-oxo-2,3-dihydro-1h-benzo[d]imidazol-1-yl)piperidine-2,6-dione 2,3-Dihydro-5,6-dimethoxy-2-(4-piperidinylmethyl)-1H-inden-1-one hydrochloride ethyl 2-oxo-2,3,9,10-tetrahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate 1-Boc-4-cyanopiperidine 3-Pyridineacrylic acid Abiraterone Ethyl Ether Vardenafil Bis-sulphonamide(Dimer) 1-nitro-3,5-dimethyl adamantine (NMEM) 3-(2-aminoethyl) benzene sulfonamide Nabumetone Impurity 5 2,2-dibromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-one 2-Amino-3,5-Dichloro-4-picoline 5-Amino-2-Ethoxypyridine