Imidazo[2,1-b]oxazole-5-carboxaldehyde, 6-(2-naphthalenyl)-, O-[(3,4-dichlorophenyl)methyl]oxime, [C(E)]-

CAS NO.：2259710-64-8
Empirical Formula: C23H15Cl2N3O2
Molecular Weight: 436.29
Update Date: 2023-03-31 09:12:58

What is Imidazo[2,1-b]oxazole-5-carboxaldehyde, 6-(2-naphthalenyl)-, O-[(3,4-dichlorophenyl)methyl]oxime, [C(E)]-?

Description

DL5050 is a Selective Agonist for the Human Constitutive Androstane Receptor. DL5050 demonstrated excellent potency and selectivity for hCAR over hPXR. DL5050 preferentially induced the expression of CYP2B6 (target of hCAR) over CYP3A4 (target of hPXR) on both the mRNA and protein levels. The selective hCAR agonist DL5050 represents a valuable tool molecule to further define the biological functions of hCAR, and may also be used as a new lead in the discovery of hCAR agonists for various therapeutic applications.

Properties of Imidazo[2,1-b]oxazole-5-carboxaldehyde, 6-(2-naphthalenyl)-, O-[(3,4-dichlorophenyl)methyl]oxime, [C(E)]-

Density	1.39±0.1 g/cm3(Predicted)
pka	5.07±0.30(Predicted)

Safety information for Imidazo[2,1-b]oxazole-5-carboxaldehyde, 6-(2-naphthalenyl)-, O-[(3,4-dichlorophenyl)methyl]oxime, [C(E)]-

Computed Descriptors for Imidazo[2,1-b]oxazole-5-carboxaldehyde, 6-(2-naphthalenyl)-, O-[(3,4-dichlorophenyl)methyl]oxime, [C(E)]-

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