I-CBP112

Synonym(s):1-[7-(3,4-Dimethoxyphenyl)-9-[[(3S)-1-methylpiperidin-3-yl]methoxy]-2,3,4,5-tetrahydr-o-1,4-benzoxazepin-4-yl]propan-1-one

CAS NO.：1640282-31-0
Empirical Formula: C27H36N2O5
Molecular Weight: 468.59
MDL number: MFCD26792587
Update Date: 2026-07-27 17:00:41

What is I-CBP112?

The Uses of I-CBP112

I-CBP112 has been used in cell culture and sample preparation, to verify the acetylation of VPS34 (vacuolar protein sorting 34), by p300 at K29, K771 and K781 and to diminish synergistic gene expression.

Biochem/physiol Actions

I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors CREBBP (CBP) and EP300 (IC50 = 0.142 and 0.625 μM, respectively). I-CBP112 has little activity against other bromodomains at concentrations up to 1 mM. For full characterization details, please see I-CBP112 on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Storage

+4°C

Properties of I-CBP112

Boiling point:	623.5±55.0 °C(Predicted)
Density	1.129±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO:63.0(Max Conc. mg/mL);134.44(Max Conc. mM) Ethanol:94.0(Max Conc. mg/mL);200.6(Max Conc. mM) Water:94.0(Max Conc. mg/mL);200.6(Max Conc. mM)
form	powder
pka	9.07±0.10(Predicted)
color	white to beige

Safety information for I-CBP112

Signal word	Warning
Pictogram(s)	Environment GHS09
GHS Hazard Statements	H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P273:Avoid release to the environment. P501:Dispose of contents/container to..…