Hydroxy-PEG2-CH2CO2t-Bu
- CAS NO.：149299-82-1
- Empirical Formula: C10H20O5
- Molecular Weight: 220.26
- MDL number: MFCD25959245
- Update Date: 2025-07-16 20:18:59
What is Hydroxy-PEG2-CH2CO2t-Bu?
Description
Hydroxy-PEG2-CH2CO2tBu is a PEG linker containing a hydroxyl group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
The Uses of Hydroxy-PEG2-CH2CO2t-Bu
Hydroxy-PEG2-CH2CO2tBu was a useful reagent in the study for potentiator-corrector agonist of cystic fibrosis mutant protein ΔF508-CFTR preparation.
Properties of Hydroxy-PEG2-CH2CO2t-Bu
| Boiling point: | 306.1±22.0 °C(Predicted) |
| Density | 1.062±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in Water, DMSO, DCM, DMF |
| pka | 14.35±0.10(Predicted) |
| color | Colourless |
Safety information for Hydroxy-PEG2-CH2CO2t-Bu
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Hydroxy-PEG2-CH2CO2t-Bu
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