HYDROXY ITRACONAZOLE

CAS NO.：112559-91-8
Empirical Formula: C35H38Cl2N8O5
Molecular Weight: 721.63
MDL number: MFCD28964104
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 03:40:26

What is HYDROXY ITRACONAZOLE?

Description

Hydroxy itraconazole (OH-ITZ) is an active metabolite of the antifungal agent itraconazole . Itraconazole is metabolized by the cytochrome P450 isoform 3A4 (CYP3A4) to form hydroxy itraconazole. Hydroxy itraconazole exhibits in vitro antifungal activity (MIC = 0.019, 0.078, and 0.078 mg/ml against C. albicans, A. fumigatus, and C. neoformans, respectively). Plasma concentration of hydroxy itraconazole is directly correlated to that of the parent compound and is used as an indicator of prophylaxis for fungal infections.

Chemical properties

Off-White Crystalline Solid

The Uses of HYDROXY ITRACONAZOLE

A metabolite of Itraconazole, an orally active antimycotic structurally related to Ketoconazole

The Uses of HYDROXY ITRACONAZOLE

A metabolite of Itraconazole, an orally active antimycotic structurally related to Ketoconazole. It is a COVID19-related research product.

What are the applications of Application

Hydroxy Itraconazole is an active antimycotic metabolite

Properties of HYDROXY ITRACONAZOLE

Melting point:	76-78°C
Boiling point:	884.7±75.0 °C(Predicted)
Density	1.44±0.1 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	Solid
pka	14.72±0.20(Predicted)
color	White to Pale Beige