HPI-1 hydrate
- CAS NO.：599150-20-6
- Molecular Weight: 0
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-08-06 15:14:14
What is HPI-1 hydrate?
Description
HPI-1 (599150-20-6) is a Hedgehog pathway inhibitor acting downstream of Smo and independently of PKA, PI3K and MAPK. It can suppress Hh pathway activation induced by loss of Su(fu) or Gli overexpression. HPI-1 inhibits both endogenous and exogenous Gli1/Gli2 activity. IC50‘s range from 0.2 to 6 μM for various cell-based assays.
References
1) Hyman?0et al. (2009)?Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade; Proc. Natl. Acad. Sci.USA,?106?14132
Properties of HPI-1 hydrate
| storage temp. | -20° |
| solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). |
| form | solid |
| color | Yellow |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
Safety information for HPI-1 hydrate
Computed Descriptors for HPI-1 hydrate
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