HNE

Synonym(s):4-Hydroxynonenal - CAS 75899-68-2 - Calbiochem

CAS NO.：75899-68-2
Empirical Formula: C9H16O2
Molecular Weight: 156.22
MDL number: MFCD00211020
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-16 07:06:08

What is HNE?

The Uses of HNE

HNE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid. 4-hydroxy Nonenal is widely used as a marker of lipid peroxidation. It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity. HNE inhibits pro-oxidant-induced Ca²⁺release from mitochondria at 10-50 μM.[Cayman Chemical]

The Uses of HNE

4-Hydroxynonenal is an irreversible inhibitor of Na+/K+-ATPase activity.

What are the applications of Application

4-Hydroxynonenal is a lipid peroxidation specific marker and irreversible inhibitor of Na+/K+-ATPase activity.

Definition

ChEBI: 4-hydroxynon-2-enal is an enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position. It has a role as a human metabolite. It is a hydroxyaldehyde, an enal and a 4-hydroxynonenal.

Properties of HNE

Boiling point:	125-127 °C(Press: 2 Torr)
Density	0.941±0.06 g/cm3(Predicted)
storage temp.	-70°C
solubility	DMF: >50 mg/ml; DMSO: >50 mg/ml; Ethanol: >50 mg/ml; PBS pH 7.2: >1 mg/ml
pka	13.31±0.20(Predicted)
form	Colorless oil.
color	Colorless to light yellow
CAS DataBase Reference	75899-68-2(CAS DataBase Reference)

Safety information for HNE

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H225:Flammable liquids H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P242:Use only non-sparking tools. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.