HL 725
Synonym(s):9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one, HCl, HL 725;HL 725;Trequinsin, Hydrochloride - CAS 78416-81-6 - Calbiochem
- CAS NO.：78416-81-6
- Empirical Formula: C24H27N3O3.ClH
- Molecular Weight: 441.95
- MDL number: MFCD01076563
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-16 07:06:08
What is HL 725?
The Uses of HL 725
PDE inhibitor
The Uses of HL 725
Trequinsin Hydrochloride is an ultrapotent inhibitor of phosphodiesterase (PDE) 3.
What are the applications of Application
Trequinsin hydrochloride is an ultrapotent inhibitor of phosphodiesterase 3
Biological Activity
Extremely potent inhibitor of cGMP-inhibited phosphodiesterase (PDE3; IC 50 = 250 pM). Potently inhibits arachidonic acid-induced aggregation of human platelets (IC 50 = 50 pM). Orally active antihypertensive agent; reduces systemic blood pressure in both normotensive and hypertensive animal models.
Storage
Desiccate at RT
Properties of HL 725
| Melting point: | 210-211 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7)) |
| storage temp. | Desiccate at RT |
| solubility | DMSO: 100 mM; Ethanol: 100 mM |
| form | Pale yellow solid |
| color | Light yellow to yellow |
Safety information for HL 725
Computed Descriptors for HL 725
New Products
N-Carbethoxy-4-piperidone 1-Aminocyclopentane carbonitrile Tetrabutylammonium perchlorate N,O-Dimethylhydroxylamine hydrochloride (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid 2-Amino-5-bromo-4-(trifluoromethyl)pyridine N-Vinylformamide 4 pentyn 1 ol Phenethyl cinnamate Dipropyl disulfide Ethyl 3-phenylpropanoate β-Bromostyrene Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 5-Bromo-1-Pentyne 1-(2-Methyl-5-nitrophenyl)guanidine Nitrate Methyl trans-4-Aminocyclohexanecarboxylate Hydrochloride N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamide 2-Pentyn-1-oL 4-NitrobenzotrifluorideRelated products of tetrahydrofuran
![(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE](https://img.chemicalbook.in/CAS/GIF/85416-75-7.gif)
You may like
-
Trequinsin, Hydrochloride CAS 78416-81-6View Details
78416-81-6 -
144-83-2 Sulfapyridine 98+View Details
144-83-2 -
29976-53-2 98+View Details
29976-53-2 -
(RS)-beta-Amino-beta-(4-bromophenyl)propionic acid 39773-47-2 98+View Details
39773-47-2 -
6638-79-5 N,O-Dimethylhydroxylamine hydrochloride 98+View Details
6638-79-5 -
674783-97-2 98+View Details
674783-97-2 -
1-Aminocyclopentane carbonitrile 98+View Details
49830-37-7 -
Tetrabutylammonium perchlorate 1923-70-2 98+View Details
1923-70-2
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.