Heat Shock Protein Inhibitor II

CAS NO.：1859-42-3
Empirical Formula: C12H11NO3
Molecular Weight: 217.22
MDL number: MFCD19104819
SAFETY DATA SHEET (SDS)
Update Date: 2025-04-18 09:51:07

What is Heat Shock Protein Inhibitor II?

Description

Heat shock protein (Hsp) inhibitor II is the active form of Hsp inhibitor I and a benzylidene lactam compound that prevents the synthesis of inducible Hsps, such as Hsp105, Hsp72, and Hsp40. Hsp inhibitor II decreases Hsp72 synthesis in vivo and reduces thermotolerance of tumors in SCC VII tumor-containing mice. At 100 μM, it inhibits the development of thermotolerance in COLO 320 DM cells. Inhibition of Hsp70 with Hsp inhibitor II in combination with amphotericin B (AmB; ) increases susceptibility of AmB-susceptible (MICs = 0.058 versus 0.27 μg/ml for combined and AmB alone, respectively) and AmB-resistant (MICs = 21.33 versus >32 μg/ml for combined and AmB alone, respectively) strains of A. fumigatus.

What are the applications of Application

Heat Shock Protein Inhibitor II is a metabolite of Heat Shock Protein Inhibitor I

Properties of Heat Shock Protein Inhibitor II

Melting point:	249-250 °C
Boiling point:	466.9±45.0 °C(Predicted)
Density	1.355±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.1 mg/ml
form	A crystalline solid
pka	14.65±0.20(Predicted)

Safety information for Heat Shock Protein Inhibitor II

Computed Descriptors for Heat Shock Protein Inhibitor II

New Products

4-Bromo-2-chlorobenzonitrile 1-Chloro-4-Methyl-2-Nitrobenzene 1,3-Diethyl-1,3-Diphenylurea 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile Methyl 2-methylquinoline-6-carboxylate 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile Chlorodehydromethyl testosterone Cisplatin Prednisolone acetate Trenbolone Enanthate Benzethonium Chloride Testosterone acetate 1,3-Di Iodo Benzene Methyl 2-oxo-2,3-dihydrobenzo[d]oxazole-7-carboxylate 3-Hydroxy-4-nitrobromobenzene 4-(2-Aminoethyl)-7-hydroxy-2H-chromoen-2-one 2-Ethyl-1,4-diaminobenzene 2-Ethylhexyl 4-aminobenzoate Boc-L-Leucinol Calcium Ascorbate Boc-Tyr-OH tert-butyl 2-oxo-1,4,9-triazaspiro[5.5]undecane-9-carboxylate 1-(1-(tert-butoxycarbonyl)piperidin-4-yl)-1H-pyrazole-4-carboxylic acid (1R,5S)-6,6-dimethylbicyclo[3.1.1]heptan-2-one