HA14-1
Synonym(s):2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester;Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylate
- CAS NO.：65673-63-4
- Empirical Formula: C17H17BrN2O5
- Molecular Weight: 409.23
- MDL number: MFCD00218213
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-27 17:00:41
What is HA14-1?
The Uses of HA14-1
HA14-1 is a cell-permeable, nonpeptidic Bcl-2 inhibitor.
What are the applications of Application
HA14-1 is a cell-permeable, nonpeptidic Bcl-2 inhibitor
Definition
ChEBI: 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylic acid ethyl ester is a 1-benzopyran.
Biological Activity
Cell-permeable inhibitor of Bcl-2 protein (IC 50 ~ 9 μ M); acts by binding to the surface pocket. Disrupts Bax/Bcl-2 interaction and induces apoptosis of tumor cells.
Biochem/physiol Actions
HA 14-1 is a nonpeptide apoptosis inducer; Bcl-2 antagonist.
Properties of HA14-1
| Melting point: | 105 °C |
| Density | 1.480 |
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO: 26 mg/mL |
| form | powder |
| color | White to light yellow |
| CAS DataBase Reference | 65673-63-4 |
Safety information for HA14-1
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for HA14-1
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