HA14-1
Synonym(s):2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester;Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylate
- CAS NO.：65673-63-4
- Empirical Formula: C17H17BrN2O5
- Molecular Weight: 409.23
- MDL number: MFCD00218213
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 23:56:52
What is HA14-1?
The Uses of HA14-1
HA14-1 is a cell-permeable, nonpeptidic Bcl-2 inhibitor.
What are the applications of Application
HA14-1 is a cell-permeable, nonpeptidic Bcl-2 inhibitor
Definition
ChEBI: 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylic acid ethyl ester is a 1-benzopyran.
Biological Activity
Cell-permeable inhibitor of Bcl-2 protein (IC 50 ~ 9 μ M); acts by binding to the surface pocket. Disrupts Bax/Bcl-2 interaction and induces apoptosis of tumor cells.
Biochem/physiol Actions
HA 14-1 is a nonpeptide apoptosis inducer; Bcl-2 antagonist.
Properties of HA14-1
| Melting point: | 105 °C |
| Density | 1.480 |
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO: 26 mg/mL |
| form | powder |
| color | White to light yellow |
| CAS DataBase Reference | 65673-63-4 |
Safety information for HA14-1
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for HA14-1
New Products
6-Hydroxy-2,4-Diaminopyrimidine 2,6-Dipicolic Acid 3-AMINO-3-(2-CHLORO-PHENYL)-PROPIONIC ACID 4-Fluorophenylglycine 1-N-Boc-3-(aminoethyl)azetidine Dimedone 1-Boc-3-(cyanomethyl)azetidine N-BOC-piperidine-4-carboxylic acid 2-Amino-5-Bromo Pyridine 2-Amino-5-Iodopyridine 2,5-Dibromopyridine METHANOL-D1(OD) 3-BROMO PYRIDINE-D4 2-BROMOACETYL BROMIDE-D2 DEUTERIUM OXIDE FOR NMR BENZENE-D6 TOLUENE-D3 5-Acetylsalicylamide 1-(3-Chlorophenyl)-4-(3-Chloropropyl) piperazine hydrochloride 4-(Methyl amino)-3-Nitro benzoic acid 3,4,5-Trimethoxy benzoic acidRelated products of tetrahydrofuran
You may like
-
Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4h-chromene-3-carboxylate 95% CAS 65673-63-4View Details
65673-63-4 -
67914-85-6 cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol (IT8)View Details
67914-85-6 -
350-03-8 3-AcetylpyridineView Details
350-03-8 -
6-Chloro-2,4-Diamino pyrimidine 156-83-2View Details
156-83-2 -
1-(4-Aminophenyl)-4-(4-methoxyphenyl)Piperazine 74852-62-3View Details
74852-62-3 -
556-08-1 4-Acetamidobenzoic acidView Details
556-08-1 -
5-Bromo-2-Chlorobenzoic acid 21739-92-4View Details
21739-92-4 -
15128-52-6View Details
15128-52-6
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.