HA-100 (hydrochloride)

CAS NO.：210297-47-5
Empirical Formula: C13H16ClN3O2S
Molecular Weight: 313.8
MDL number: MFCD01310980
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 03:50:31

What is HA-100 (hydrochloride)?

Description

HA-100 is an isoquinoline compound with an added piperazinylsulfonyl group that acts as an inhibitor of protein kinases (PKs), including PKA, PKC, and PKG (IC₅₀s = 8, 12, and 4 μM, respectively). It less effectively blocks the activity of myosin light chain kinase (IC₅₀ = 240 μM).

The Uses of HA-100 (hydrochloride)

HA-100 dihydrochloride is an inhibitor of MYLK, PKA, and PKC.

What are the applications of Application

HA-100 dihydrochloride is a isoquinoline compound that can act as an inhibitor of protein kinases including PKA, PKG and PKC

References

[1] hagiwara m, inagaki m, watanabe m, et al. selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives[j]. molecular pharmacology, 1987, 32(1): 7-12.
[2] krebs e g. protein kinases[j]. current topics in cellular regulation, 1972, 5: 99-133.

Properties of HA-100 (hydrochloride)

storage temp.	Store at -20°C
solubility	insoluble in EtOH; ≥131.8 mg/mL in H2O; ≥19.17 mg/mL in DMSO with ultrasonic
form	A crystalline solid

Safety information for HA-100 (hydrochloride)

Computed Descriptors for HA-100 (hydrochloride)

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