GYKI 46903
- CAS NO.：142999-59-5
- Empirical Formula: C17H21ClFNO2
- Molecular Weight: 325.81
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-21 10:31:43
What is GYKI 46903?
Description
GYKI-46903 is a non-competitive antagonist for 5-HT3 receptors. In displacement studies, the pIC50 values of GYKI-46903 against [3H]granisetron binding to rat cerebral cortex membranes were 6.91. GYKI-46903, when administered by intravenous infusion, antagonized the decrease in heart rate evoked by serotonin (Bezold-Jarisch reflex) in anaesthetized rats, and the maximal reversal was less than 50%.
Safety information for GYKI 46903
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