GW441756

CAS NO.：504433-23-2
Empirical Formula: C17H13N3O
Molecular Weight: 275.31
MDL number: MFCD08703104
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-27 17:00:41

What is GW441756?

Description

GW-441756 (504433-23-2) is a potent and selective TrkA kinase inhibitor (IC50 = 2 nM).

The Uses of GW441756

GW 441756 is an effective Trk binder, a novel bioactive molecule used in the treatment of neuroblastoma in infants.

What are the applications of Application

GW-441756 is a specific TrkA tyrosine kinase inhibitor

Definition

ChEBI: 3-[(1-methyl-3-indolyl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one is a member of indoles.

Biological Activity

Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC 50 = 2 nM). Displays > 100-fold selectivity over a range of other kinases.

Storage

Store at RT

References

1) Wood et al. (2004) Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg. Med. Chem. Lett. 14 953 2) Takemoto et al. (2015) Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury; Environ. Toxicol. Pharmacol. 40 199 [Focus Citation]

Properties of GW441756

Boiling point:	568.0±50.0 °C(Predicted)
Density	1.31±0.1 g/cm3(Predicted)
storage temp.	Store at RT
solubility	Soluble in DMSO (up to 5 mg/ml).
form	solid
pka	11.04±0.20(Predicted)
color	Orange
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety information for GW441756

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.