GW 842166X

CAS NO.：666260-75-9
Empirical Formula: C18H17Cl2F3N4O2
Molecular Weight: 449.25
MDL number: MFCD11045840
EINECS: 200-258-5
SAFETY DATA SHEET (SDS)
Update Date: 2026-08-07 18:09:57

What is GW 842166X?

Description

The peripheral cannabinoid (CB₂) receptor is a G protein-coupled receptor (GPCR) that is localized predominantly in immune cells, monocytes, macrophages, and in several peripheral organs and binds the active component of cannabis, Δ⁹-tetrahydrocannabinol, as well as anandamide, an endogenous CB receptor ligand. GW 842166X is a peripheral cannabinoid (CB₂) receptor agonist with ED₅₀ values of 91 and 63 nM in rat and human, respectively. When administered orally to rats in the Freund’s complete adjuvant (FCA) model of inflammatory pain, GW 842166X is highly potent with an ED₅₀ value of 0.1 mg/kg and full reversal of hyperalgesia at 0.3 mg/kg.

The Uses of GW 842166X

GW-842166X is pyrimidine ester based compound that is known as a highly selective CB2 receptor agonist for the treatment of inflammatory and neuropathic pain.

What are the applications of Application

GW 842166X is an agonist of the CB2 receptor

Definition

ChEBI: 5-pyrimidinecarboxamide, 2-[(2,4-dichlorophenyl)amino]-n-[(tetrahydro-2h-pyran-4-yl)methyl]-4-(trifluoromethyl)- is a dichlorobenzene.

Properties of GW 842166X

storage temp.	Store at -20°C
solubility	DMF:20.0(Max Conc. mg/mL);44.52(Max Conc. mM) DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.56(Max Conc. mM) DMSO:37.77(Max Conc. mg/mL);84.07(Max Conc. mM) Ethanol:0.3(Max Conc. mg/mL);0.67(Max Conc. mM)
form	Powder
color	White to off-white

Safety information for GW 842166X

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.