GW 6471

Synonym(s):N-((2S)-2-(((1Z)-1-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)prop-1-enyl)amino)-3-(4-(2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy)phenyl)propyl)propanamide

CAS NO.：880635-03-0
Empirical Formula: C35H36F3N3O4
Molecular Weight: 619.67
MDL number: MFCD07784503
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-14 16:49:18

What is GW 6471?

The Uses of GW 6471

GW 6471 is a peroxisome proliferator-activated receptor α (PPARα) antagonist. GW 6471 has been shown to enhance the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR.

What are the applications of Application

GW6471 is a complete inhibitor of PPARα that allows interaction with co-repressors

General Description

GW6471 prevents apoptosis and cell cycle arrest at G₀/G₁ in renal cell carcinoma. It reduces enhanced fatty acid oxidation and oxidative phosphorylation associated with glycolysis inhibition.

Biochem/physiol Actions

GW6471 is a PPARα antagonist, which completely inhibits GW409544-induced activation of PPARα with an IC50 = 0.24 μM. GW6471 induces a PPARα conformation that interacts efficiently with co-repressors.

Storage

Store at +4°C

Properties of GW 6471

Density	1.204±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 15 mg/mL
form	solid
pka	15.90±0.46(Predicted)
color	off-white

Safety information for GW 6471

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.