GUVACINE HYDROCHLORIDE
- CAS NO.：498-96-4
- Empirical Formula: C6H9NO2
- Molecular Weight: 127.14
- MDL number: MFCD01365700
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-04 15:11:55
What is GUVACINE HYDROCHLORIDE?
The Uses of GUVACINE HYDROCHLORIDE
Guvacine Hydrochloride is a GABA uptake inhibitor (hGABA T-1, rGABA T-2, hGABA T-3 and hBGT-1) (1,2,3). Gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain (4). Guvacine Hydrochloride may be useful for treating neuropsychiatric disorders.
Definition
ChEBI: A alpha,beta-unsaturated monocarboxylic acid that is nicotinic acid which has been hydrogenated at the 1-2 and 5-6 positions of the pyridine ring.
Biological Activity
Specific GABA uptake inhibitor. IC 50 values are 14, 58, 119 and 1870 mM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively.
Properties of GUVACINE HYDROCHLORIDE
| Melting point: | 295°C (rough estimate) |
| Boiling point: | 235.91°C (rough estimate) |
| Density | 1.1931 (rough estimate) |
| refractive index | 1.4645 (estimate) |
| storage temp. | Store at RT |
| solubility | H2O: soluble |
| form | solid |
| pka | 3.61±0.20(Predicted) |
| color | white |
| CAS DataBase Reference | 498-96-4 |
Safety information for GUVACINE HYDROCHLORIDE
Computed Descriptors for GUVACINE HYDROCHLORIDE
New Products
2-(3-Methyl-1,2,4-oxadiazol-5-yl)acetic acid (as potassium salt) 2-fluoro-4-iodoaniline 4-Iodo-3,5-dimethylbenzonitrile Atorvastatin amide impurity/Atorvastatin EP Impurity F(Calcium Salt) Lantanoprost rc B Clidinium Bromide Impurity Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity N-Nitroso hydroxy Cetrizine EP Impurity-A (4-Fluoro-2-methoxy-5-nitro- phenyl)-[4- (1-methyl-1H- indol-3- yl)-pyrimidin-2-yl]- amine 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole tert-butyl 4-(6-((7-cyclo pentyl -6-(dimethyl carbamoyl) -7H-pyrrolo [2,3-d]pyrimidin-2-yl) amino)pyridin-3-yl) piperazine-1-carboxylate 2-Fluoro-4-nitrotoluene 1-(2-amino-5-hydroxy phenyl)propan-1-one (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3- amine 3-(Dimethylamino)benzoic acid 2-Amino-5-chloropyridine 4-(Methylamino)-3-nitrobenzoic Acid 5-Chloro-2-Nitroaniline 3,5-dibenzyloxy Acetophenone 2,4-Diamino-6-hydroxypyrimidine 2-Chloro Benzylcyanide 3-chlorobenzyl cyanide 3,4 Diethoxy BenzylcyanideRelated products of tetrahydrofuran
![N-(3-CHLOROPHENYL)-8-METHOXY-5-OXO-1,5-DIHYDRO-2H-CHROMENO[3,4-C]PYRIDINE-3(4H)-CARBOXAMIDE](https://img.chemicalbook.in/StructureFile/ChemBookStructure7/GIF/CB8430298.gif)
![3-(4-CHLOROBENZOYL)-8-METHOXY-1,2,3,4-TETRAHYDRO-5H-CHROMENO[3,4-C]PYRIDIN-5-ONE](https://img.chemicalbook.in/StructureFile/ChemBookStructure7/GIF/CB3455173.gif)
![1,2,5,6-TETRAHYDRO-1-[2-[[(DIPHENYLMETHYLENE)AMINO]OXY]ETHYL]-3-PYRIDINECARBOXYLIC ACID HYDROCHLORIDE](https://img.chemicalbook.in/CAS/GIF/145645-62-1.gif)
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