GUVACINE HYDROCHLORIDE
- CAS NO.：498-96-4
- Empirical Formula: C6H9NO2
- Molecular Weight: 127.14
- MDL number: MFCD01365700
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-04 15:11:55
What is GUVACINE HYDROCHLORIDE?
The Uses of GUVACINE HYDROCHLORIDE
Guvacine Hydrochloride is a GABA uptake inhibitor (hGABA T-1, rGABA T-2, hGABA T-3 and hBGT-1) (1,2,3). Gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain (4). Guvacine Hydrochloride may be useful for treating neuropsychiatric disorders.
Definition
ChEBI: A alpha,beta-unsaturated monocarboxylic acid that is nicotinic acid which has been hydrogenated at the 1-2 and 5-6 positions of the pyridine ring.
Biological Activity
Specific GABA uptake inhibitor. IC 50 values are 14, 58, 119 and 1870 mM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively.
Properties of GUVACINE HYDROCHLORIDE
| Melting point: | 295°C (rough estimate) |
| Boiling point: | 235.91°C (rough estimate) |
| Density | 1.1931 (rough estimate) |
| refractive index | 1.4645 (estimate) |
| storage temp. | Store at RT |
| solubility | H2O: soluble |
| form | solid |
| pka | 3.61±0.20(Predicted) |
| color | white |
| CAS DataBase Reference | 498-96-4 |
Safety information for GUVACINE HYDROCHLORIDE
Computed Descriptors for GUVACINE HYDROCHLORIDE
New Products
DL-beta-(3-Bromophenyl)alanine Tetrabutylammonium perchlorate N,O-Dimethylhydroxylamine hydrochloride (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid 2-Amino-5-bromo-4-(trifluoromethyl)pyridine（RM for Indian lab) N,N CARBONYL DIIMIDAZOLE Levothyroxine Impurity-F Montelukast EP Impurity-D/Montelukast USP Related Compound C Atorvastatin FXA Impurity/Atorvastatin Cyclic 6-Hydroxy Impurity Sodium Salt Isosulfan blue Keto N-Oxide Impurity Ivermectin Impurity F N-Nitroso des Methyl Tramadol/N-Nitroso-N-Desmethyl-Tramadol (R)-BoroLeu-(+)-Pinanediol-CF3COOH 1,4-bis(methylsulfonyl)butane 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. 5-Methyl-1,3-benzenediacetonitrile 4-Fluorothiophenol 1-methyl amino-2,4-dinitro benzene CSA (DL-10-Camphorsulfonic Acid) 2-Hydroxy-4-methylnicotinic acid 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (2S)-1-((2S,3S)-3-(2-methylbutyl)-4-oxooxetan-2-yl)pentadecan-2-yl formylleucinate 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethane-1-sulfonyl chloride S-(1-(3,5-dichlorophenyl)-2,2,2-trifluoroethyl) ethanethioateRelated products of tetrahydrofuran
![N-(3-CHLOROPHENYL)-8-METHOXY-5-OXO-1,5-DIHYDRO-2H-CHROMENO[3,4-C]PYRIDINE-3(4H)-CARBOXAMIDE](https://img.chemicalbook.in/StructureFile/ChemBookStructure7/GIF/CB8430298.gif)
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