GUVACINE HYDROCHLORIDE
- CAS NO.：498-96-4
- Empirical Formula: C6H9NO2
- Molecular Weight: 127.14
- MDL number: MFCD01365700
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-04 15:11:55
What is GUVACINE HYDROCHLORIDE?
The Uses of GUVACINE HYDROCHLORIDE
Guvacine Hydrochloride is a GABA uptake inhibitor (hGABA T-1, rGABA T-2, hGABA T-3 and hBGT-1) (1,2,3). Gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain (4). Guvacine Hydrochloride may be useful for treating neuropsychiatric disorders.
Definition
ChEBI: A alpha,beta-unsaturated monocarboxylic acid that is nicotinic acid which has been hydrogenated at the 1-2 and 5-6 positions of the pyridine ring.
Biological Activity
Specific GABA uptake inhibitor. IC 50 values are 14, 58, 119 and 1870 mM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively.
Properties of GUVACINE HYDROCHLORIDE
| Melting point: | 295°C (rough estimate) |
| Boiling point: | 235.91°C (rough estimate) |
| Density | 1.1931 (rough estimate) |
| refractive index | 1.4645 (estimate) |
| storage temp. | Store at RT |
| solubility | H2O: soluble |
| form | solid |
| pka | 3.61±0.20(Predicted) |
| color | white |
| CAS DataBase Reference | 498-96-4 |
Safety information for GUVACINE HYDROCHLORIDE
Computed Descriptors for GUVACINE HYDROCHLORIDE
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