GUANIDINE

The Uses of GUANIDINE

Two derivatives of guanidine, dodine (27) and iminoctadine (28), are being used as agricultural fungicides . The former was reported in 1957 (28), whereas the latter is new as a member of the multisite inhibitor group of fungicides. Both have one or two guanidine group(s) connected to a long chain alkyl or iminodi( polymethylene) group and seem to belong to a kind of cationic surface active agent.

Definition

A strongly basic crystalline organic compound which can be nitrated to make a powerful explosive. It is also used in making dyestuffs, medicines and polymer resins.

Definition

guanidine: A crystalline basic compoundHN:C(NH₂)₂, related to urea.

Biological Functions

Guanidine hydrochloride is the drug of choice in the management of patients with myasthenic syndrome and may be of use in the treatment of botulinum intoxication. Its ability to enhance transmitter release may involve a block of K⁺ channels and prolongation of the nerve action potential.

Agricultural Uses

Guanidine, a colorless crystal with a melting point of 50°C, is soluble in water and alcohol. It is an analogue of urea and is also known as amino urea. Guanidine synthesis occurs by treating urea with ammonia under pressure or by heating calcium cyanamide with ammonium iodide.
Guanidine forms a number of salts like the carbonate, phosphate, nitrate, sulphate and hydrochloride which can be used as fertilizers.