GSK503A)

CAS NO.：1366234-01-6
Empirical Formula: C18H21ClFN3OS
Molecular Weight: 381.9
Update Date: 2025-04-18 09:51:12

What is GSK503A)?

Description

GSK 2833503A is a potent, and selective inhibitor of TRPC3/6 channels with IC50 of 4 nM/5 nM, respectively. It dispalys >100-fold selectivity over other calcium-permeable channels. It has 100-fold greater potency for TRPC3 compared with Pyr3. GSK 2833503A (dose-dependent) blocks cell hypertrophy signaling triggered by angiotensin II or endothelin-1 in HEK293T cells as well as in neonatal and adult cardiac myocytes.

Storage

Store at -20°C

Properties of GSK503A)

Boiling point:	512.1±60.0 °C(Predicted)
Density	1.291±0.06 g/cm3(Predicted)
solubility	Soluble to 100 mM in DMSO and to 20 mM in ethanol
pka	2.52±0.10(Predicted)

Safety information for GSK503A)

Computed Descriptors for GSK503A)

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