GSK269962A

CAS NO.：850664-21-0
Empirical Formula: C29H30N8O5
Molecular Weight: 570.6
MDL number: MFCD09970310
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-16 16:10:54

What is GSK269962A?

Description

Two Rho-associated kinases (ROCKS), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. GSK269962 is a selective ROCK inhibitor with IC₅₀ values of 1.6 and 6 nM for ROCK1 and ROCK2, respectively. It displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. GSK269962 has been shown to block the generation of inflammatory cytokines in lipopolysaccharide-stimulated monocytes and to induce vasorelaxation in preconstricted rat aorta (IC₅₀ = 35 nM). Oral administration of 1-30 mg/kg GSK269962 can dose-dependently lower blood pressure in spontaneously hypertensive rats.

The Uses of GSK269962A

GSK 269962 is a potent and selective Rho kinase (ROCK) inhibitor.

What are the applications of Application

GSK 269962 is a potent inhibitor of Rho kinase (ROCK)

Storage

Store at +4°C

Properties of GSK269962A

Melting point:	125 - 127°C
Density	1.45
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	13.19±0.70(Predicted)
color	Off-White

Safety information for GSK269962A

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for GSK269962A

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