GSK2110183B

CAS NO.：1047645-82-8
Empirical Formula: C18H18Cl3FN4OS
Molecular Weight: 463.78
MDL number: MFCD28167824
SAFETY DATA SHEET (SDS)
Update Date: 2025-10-29 15:43:00

What is GSK2110183B?

The Uses of GSK2110183B

Afuresertib is a selective, orally bioavailable inhibitor of Akt1, 2, and 3 with Ki values of 0.08, 2, and 2.6 nM, respectively. It preferentially inhibits the proliferation of human cancer cell lines with Akt pathway activation and various cell lines derived from hematologic malignancies with minimal effect on glucose homeostasis. Afuresertib demonstrates activity against multiple myeloma in both preclinical and clinical models.[Cayman Chemical]

Properties of GSK2110183B

storage temp.	Store at -20°C, protect from light, stored under nitrogen
solubility	DMSO:65.0(Max Conc. mg/mL);140.15(Max Conc. mM) DMF:50.0(Max Conc. mg/mL);107.81(Max Conc. mM) Ethanol:50.0(Max Conc. mg/mL);107.81(Max Conc. mM) Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.08(Max Conc. mM)
form	A crystalline solid
color	Yellow to brown

Safety information for GSK2110183B

Computed Descriptors for GSK2110183B

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