GSK106 (hydrochloride)

CAS NO.：1652591-82-6
Empirical Formula: C24H28ClN5O
Molecular Weight: 437.965
MDL number: MFCD33029315
Update Date: 2026-04-24 14:58:31

What is GSK106 (hydrochloride)?

Description

Protein arginine deiminase 4 (PAD4) mediates the transformation of protein arginine into citrulline. Citrullination of proteins has normal roles in gene regulation and pathological roles in immunological and inflammatory diseases. GSK106 is an inactive control for the selective PAD4 inhibitors, GSK484 and GSK199 . It does not inhibit PAD4 nor does it prevent the citrullination of PAD4 target proteins or the formation of neutrophil extracellular traps in mouse or human neutrophils (IC₅₀s > 100 μM). See the Structural Genomics Consortium (SGC) website for more information on both GSK484 and GSK106.

The Uses of GSK106 (hydrochloride)

(3-Amino-1-piperidinyl)[2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzimidazol-6-yl]-methanone Hydrochloride is structurally similar to (3-Amino-1-piperidinyl)[1-methyl-2-(1-methyl-1H-indol-2-yl)-1H-benzimidazol-5-yl]-methanone TFA Salt (G797395) and is suitable to use as a control to identify inhibitors for protein arginine deiminase 4 (PAD4).

Properties of GSK106 (hydrochloride)

storage temp.	Store at -20°C
solubility	DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
form	A crystalline solid
color	Off-white to light yellow

Safety information for GSK106 (hydrochloride)

Computed Descriptors for GSK106 (hydrochloride)

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