GSK-A1
- CAS NO.：1416334-69-4
- Empirical Formula: C29H27FN6O4S
- Molecular Weight: 574.63
- MDL number: MFCD29770784
- Update Date: 2026-01-13 11:25:22
What is GSK-A1?
Biological Activity
GSK-A1 is an inhibitor of phosphatidylinositol 4-kinase IIIα (PI4KIIIα; IC50 = 3.16 nM).1 It is selective for PI4KIIIα over PI4KIIIβ, PI3Kα, PI3Kβ, and PI3Kδ (IC50s = >50 nM) but also inhibits PI3Kγ (IC50 = 15.8 nM). GSK-A1 decreases the levels of phosphatidylinositol 4-phosphate (PtdIns-(4)-P1) but not PtdIns-(4,5)-P2 in HEK293 cells expressing the angiotensin II type 1 (AT1) receptor (IC50 = 3 nM). GSK-A1 inhibits hepatitis C virus (HCV) genotype 1a and 1b replication.
References
1.Bojjireddy, N., Botyanszki, J., Hammond, G., et al.Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levelsJ. Biol. Chem.289(9)6120-6132(2014)
Properties of GSK-A1
| storage temp. | Store at -20°C |
| solubility | DMSO: 2 mg/ml |
| form | A solid |
| color | White to off-white |
Safety information for GSK-A1
Computed Descriptors for GSK-A1
New Products
Dexamethasone Sodium Phosphate 2-(2-Ethoxyphenoxy)ethyl bromide 1,3-Dibromo-2,2-dimethoxypropane 8-Bromo-7-(2-butynyl)-3-methyl xanthine 5-Chlorothiophene-2-carboxylic acid 8-Bromo-3-methyl xanthine Maleic hydrazide m-Tolualdehyde p-Anisaldehyde 2-Bromobenzaldehyde 4-Fluorobenzaldehyde 1-Propyl-4-piperidone 3-Amino-3-(3-fluorophenyl)propanoic acid 2-Fluoro-6-iodobenzoic acid 3-(4-Bromo-3-methyl-2-oxo-2,3-dihydro-1h-benzo[d]imidazol-1-yl)piperidine-2,6-dione 2,3-Dihydro-5,6-dimethoxy-2-(4-piperidinylmethyl)-1H-inden-1-one hydrochloride ethyl 2-oxo-2,3,9,10-tetrahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate 1-Boc-4-cyanopiperidine 3-Pyridineacrylic acid Abiraterone Ethyl Ether Vardenafil Bis-sulphonamide(Dimer) 1-nitro-3,5-dimethyl adamantine (NMEM) 3-(2-aminoethyl) benzene sulfonamide Nabumetone Impurity 5Related products of tetrahydrofuran
![N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide](https://img.chemicalbook.in/CAS2/GIF/864082-47-3.gif)
![Benzeneacetamide, α-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]-](https://img.chemicalbook.in/CAS/20211123/GIF/2170137-61-6.gif)
You may like
-
GSK-A1 >95% CAS 1416334-69-4View Details
1416334-69-4 -
141-30-0 3,6-Dichloropyridazine 98%View Details
141-30-0 -
Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate 27143-07-3 98%View Details
27143-07-3 -
94-71-3 98%View Details
94-71-3 -
Methyl 2-methoxy-5-sulfamoylbenzoate 33045-52-2 98%View Details
33045-52-2 -
3,6-Dichloro-4-Isopropylpyridazine 107228-51-3 98%View Details
107228-51-3 -
4640-67-9 98%View Details
4640-67-9 -
2-[(2-Ethoxyphenoxy)methyl]oxirane 98%View Details
5296-35-5