GSK-626616
Synonym(s):(5Z)-2-(2,6-Dichloroanilino)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolone;(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone;(5Z)-5-(6-Quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5H)-one;(Z)-2-(2,6-Dichlorophenylamino)-5-(quinoxalin-6-ylmethylene)thiazol-4(5H)-one;
- CAS NO.：1025821-33-3
- Empirical Formula: C18H10Cl2N4OS
- Molecular Weight: 401.27
- MDL number: MFCD31689261
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-14 09:55:04
What is GSK-626616?
The Uses of GSK-626616
GSK-626616 is a potent and selective DYRK inhibitor (IC50 = 0.7 nM for DYRK3, similar potency for DYRK1 and 2). Exhibits ~20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened. Enhances number of CFU-E stimulated by Epo from human marrow. Increases hemoglobin levels in anemic mice. Orally bioavailable.
Storage
Store at +4°C
Properties of GSK-626616
| Melting point: | 281 - 282oC |
| Boiling point: | 574.8±60.0 °C(Predicted) |
| Density | 1.55±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator, under inert atmosphere |
| solubility | Chloroform (Slightly, Heated), Methanol (Slightly) |
| form | Solid |
| pka | -0.94±0.20(Predicted) |
| color | Pale Yellow to Light Yellow |
Safety information for GSK-626616
Computed Descriptors for GSK-626616
New Products
4-Nitrobenzoic acid p-Tolualdehyde 4-Chlorobenzaldehyde 2-Fluorobenzaldehyde Diethylene glycol monomethyl ether 3-Chlorobenzaldehyde N5-(2-aminoethyl)pyridine-2,5-diamine hydrochloride N-Nitroso Desloratadine Ornidazole EP impurity C Domperidone Impurity Valsartan Desalkyl Clomiphene benzophenone analog 3,5-Dibromo-2-Nitropyridine Tert-butyl 4-(6-nitropyridine-3-yl)piperazine-1-carbaxylate 1-Methyl-4-(6-aminopyridin-3-yl)piperazine 2,5-Dichloro-4-Methylpyridine 2,4,5-Trichloropyridine 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amineRelated products of tetrahydrofuran
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