GNE 900

CAS NO.：1200126-26-6
Empirical Formula: C23H21N5
Molecular Weight: 367.45
MDL number: MFCD28009364
Update Date: 2026-04-17 13:05:51

What is GNE 900?

Description

GNE-900 is an ATP-competitive, selective, and orally bioavailable ChK1 inhibitor. In combination with chemotherapeutic agents, GNE-900 sustains ATR/ATM signaling, enhances DNA damage, and induces apoptotic cell death. GNE-900 has little single-agent activity in the absence of chemotherapy and does not grossly potentiate the cytotoxicity of gemcitabine in normal bone marrow cells. In vivo scheduling studies show that optimal administration of the ChK1 inhibitor requires a defined lag between gemcitabine and GNE-900 administration. (Mol Cancer Ther; 12(10); 1968-80).

Properties of GNE 900

form	Solid
color	Light yellow to brown

Safety information for GNE 900

Computed Descriptors for GNE 900

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