GKK1032B

CAS NO.：358375-11-8
Empirical Formula: C32H39NO4
Molecular Weight: 501.66
Update Date: 2026-04-14 09:55:04

What is GKK1032B?

Description

GKK1032B is a fungal metabolite that has antiproliferative and antibacterial activities. GKK1032B inhibits the growth of HeLa S3 cervical and MCF-7 breast cancer cells and Vero cells. It also inhibits the growth of B. subtilis and M. tuberculosis.

in vitro

Among them, GKK1032B showed significant cytotoxicity against human osteosarcoma cell line MG63 with an IC50 value of 3.49 μmol·L-1, and a primary mechanistic study revealed that it induced the apoptosis of MG63 cellsvia caspase pathway activation._x000D_ _x000D_ Reference: Chin J Nat Med. 2022 Jan;20(1):67-73. https://pubmed.ncbi.nlm.nih.gov/35101251/

Properties of GKK1032B

Boiling point:	653.9±55.0 °C(Predicted)
Density	1.130±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Dichloromethane: soluble; DMSO: soluble; Ethanol: soluble
form	A solid
pka	8.99±0.70(Predicted)

Safety information for GKK1032B

Computed Descriptors for GKK1032B

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