GGTI 298 trifluoroacetate salt hydrate

Synonym(s):N-[[4-(2-(R)-Amino-3-mercaptopropyl)amino]-2-naphthylbenzoyl]leucine methyl ester trifluoroacetate salt hydrate

CAS NO.：1217457-86-7
Empirical Formula: C29H34F3N3O5S
Molecular Weight: 593.66
MDL number: MFCD06409252
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 00:04:25

GGTI 298 trifluoroacetate salt hydrate Structural

What is GGTI 298 trifluoroacetate salt hydrate?

The Uses of GGTI 298 trifluoroacetate salt hydrate

GGTI 298 trifluoroacetate salt hydrate has been used as a geranylgeranyltransferase I (GGTase I) inhibitor:

to study the anticancer effects of statins along with GGTI 298
to study its combinatorial effects with FTI-277 on statin-mediated activation of extracellular signal-regulated kinase 5 (ERK5) in the human endothelium
to evaluate the effect of protein geranylgeranylation (GG) inhibition on the breast cancer stem cell (CSC) population

What are the applications of Application

GGTI 298 is a CAAZ peptidomimetic GGTase I inhibitor

Biochem/physiol Actions

GGTI 298 is a cell-permeable, prodrug form of the geranylgeranyltransferase I (GGTase I) inhibitor GGTI-297. It inhibits the processing of Rap 1A without effecting the processing of H-Ras.

Storage

Store at -20°C

Properties of GGTI 298 trifluoroacetate salt hydrate

Melting point:	99.5-100°C
storage temp.	-20°C
solubility	DMSO: >20mg/mL
form	film &_& lyophilized
color	colorless

Safety information for GGTI 298 trifluoroacetate salt hydrate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.