GC376

CAS NO.：1416992-39-6
Empirical Formula: C21H32N3NaO8S
Molecular Weight: 509.55
MDL number: MFCD31382192
Update Date: 2026-04-22 18:57:36

What is GC376?

Description

GC376 is an inhibitor of the main protease M^pro (3CL^pro) in coronaviruses as well as picornaviruses. This broad-spectrum antiviral compound has been used as investigational veterinary drug for treatment of feline infectious peritonitis virus (FIPV) infections. Recent studies also showed that GC376 inhibits the main protease M^pro (3CL^pro) from SARS-CoV-2 with IC₅₀ of 0.03 μM and EC₅₀ of 3.37 μM.

The Uses of GC376

GC 376 sodium is a potential small molecule inhibitor which may be able to reduce the viral load of SARS-CoV-2 3CLpro.

Properties of GC376

storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	DMF: 10 mg/ml,DMSO: 10 mg/ml,PBS (pH 7.2): 10 mg/ml
form	A crystalline solid

Safety information for GC376

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

Computed Descriptors for GC376

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