GC376
- CAS NO.：1416992-39-6
- Empirical Formula: C21H32N3NaO8S
- Molecular Weight: 509.55
- MDL number: MFCD31382192
- Update Date: 2026-07-16 07:06:08
What is GC376?
Description
GC376 is an inhibitor of the main protease Mpro (3CLpro) in coronaviruses as well as picornaviruses. This broad-spectrum antiviral compound has been used as investigational veterinary drug for treatment of feline infectious peritonitis virus (FIPV) infections. Recent studies also showed that GC376 inhibits the main protease Mpro (3CLpro) from SARS-CoV-2 with IC50 of 0.03 μM and EC50 of 3.37 μM.
The Uses of GC376
GC 376 sodium is a potential small molecule inhibitor which may be able to reduce the viral load of SARS-CoV-2 3CLpro.
Properties of GC376
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMF: 10 mg/ml,DMSO: 10 mg/ml,PBS (pH 7.2): 10 mg/ml |
| form | A crystalline solid |
Safety information for GC376
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
Computed Descriptors for GC376
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