GAMMA-CHLOROBUTYROPHENONE
- CAS NO.：939-52-6
- Empirical Formula: C10H11ClO
- Molecular Weight: 182.65
- MDL number: MFCD00001005
- EINECS: 213-362-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 02:17:55
What is GAMMA-CHLOROBUTYROPHENONE?
The Uses of GAMMA-CHLOROBUTYROPHENONE
4-Chlorobutyrophenone may be used in the preparation of silyl enol ether, Z-4-chloro-1-phenyl-1-trimethylsilyloxybut-1-ene. It may be used as starting material in the preparation of 8-arylimidazopyridines.
Synthesis Reference(s)
Journal of the American Chemical Society, 79, p. 1455, 1957 DOI: 10.1021/ja01563a049
General Description
4-Chlorobutyrophenone is a chloro ketone. Preparation of 4-chlorobutyrophenone is reported.
Purification Methods
Fractionate the ketone several times using a short column. It recrystallises from pet ether at -20o as glistening white rosettes and is filtered at 0o, and dried in a vacuum desiccator over H2SO4. The semicarbazone has m 136-137o. [Conant et al. J Am Chem Soc 46 1882 1924, Cloke J Chem Soc 1174 1929, Hart & Curtis J Am Chem Soc 79 931 1957, Beilstein 7 IV 711.]
Properties of GAMMA-CHLOROBUTYROPHENONE
| Melting point: | 19-20 °C (lit.) |
| Boiling point: | 130-133 °C4 mm Hg |
| Density | 1.137 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| BRN | 878974 |
| CAS DataBase Reference | 939-52-6(CAS DataBase Reference) |
Safety information for GAMMA-CHLOROBUTYROPHENONE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for GAMMA-CHLOROBUTYROPHENONE
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![4-Chloro-1-[4-(1-methylethyl)phenyl]-1-butanone](https://img.chemicalbook.in/CAS/GIF/70289-38-2.gif)
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