FzM1

CAS NO.：1680196-54-6
Empirical Formula: C21H16N2O2S
Molecular Weight: 360.43
MDL number: MFCD29079017
Update Date: 2026-05-28 04:19:09

What is FzM1?

Description

Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins initiate cell signaling by binding Frizzled (Fz) receptors, a family of G protein-coupled receptors. FzM1 is an allosteric ligand of Fz4. At 10 μM, it inhibits nuclear translocation of β-catenin in U87MG glioma cells treated with lithium chloride, a GSK3 inhibitor that enhances the Wnt canonical signaling pathway. FzM1 impairs the ability of U87MG cells to form neurospheres in culture and stimulates the differentiation of Caco-2 epithelial colorectal adenocarcinoma cells.

Properties of FzM1

Boiling point:	518.3±50.0 °C(Predicted)
Density	1.401±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 12 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.2 mg/ml; DMSO: 10 mg/ml
form	A crystalline solid
pka	9.42±0.10(Predicted)
color	White to light brown

Safety information for FzM1

Computed Descriptors for FzM1

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