FPG PROTEIN

Synonym(s):Fapy DNA glycosylase;Formamidopyrimidine DNA glycosylase;MutM

CAS NO.：78783-53-6
Molecular Weight: 0
MDL number: MFCD02264758
Update Date: 2026-04-24 14:59:10

What is FPG PROTEIN?

The Uses of FPG PROTEIN

Fpg Protein from Escherichia coli has been used for the assessment of DNA oxidative damage using comet assay.

General Description

Fpg contains two domains separated by a flexible hinge.

Biochem/physiol Actions

Fpg is a key enzyme in the DNA base excision repair pathway (BER). It catalyses the excision of a broad spectrum of modified purines. Fpg has both DNA glycosylase activity that removes the mutated base and AP-lyase activity that releases ribose leaving both 5′- and 3′-phosphorylated ends in the DNA. The zinc finger motif at its C-terminus is responsible for the DNA binding and AP-lyase activity. In addition, its N-terminal proline acts as a nucleophile to produce a Schiff base intermediate that is essential for enzyme action.

Properties of FPG PROTEIN

storage temp.	-20°C
form	buffered aqueous glycerol solution

Safety information for FPG PROTEIN

Computed Descriptors for FPG PROTEIN

New Products

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