Fotemustine
Synonym(s):(+-)-Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate;Muphoran;Mustophorane;P-[1-[[[(2-Chloroethyl)nitrosoamino]carbonyl]amino]ethyl]-phosphonic acid diethyl ester;S 10036
- CAS NO.：92118-27-9
- Empirical Formula: C9H19ClN3O5P
- Molecular Weight: 315.69
- MDL number: MFCD00866278
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:43
What is Fotemustine?
Description
Fotemustine is a new nitrosourea reportedly effective in the treatment of disseminated malignant melanoma, with only mild hematological toxicity. Response rate is generally lower in patients with colonic, breast, head and neck cancer.
Originator
Servier (France)
The Uses of Fotemustine
Fotemustine is used in patients malignant gliomas to improve the efficacy of radiotherapy. Used in the treatment of glioblastomas.
Definition
ChEBI: Diethyl (1-{[(2-chloroethyl)(nitroso)carbamoyl]amino}ethyl)phosphonate is a member of the class of N-nitrosoureas that is ethyl diethylphosphonate in the hydrogen at position 1 of the ethyl group attached to the phosphorus has been replaced by a [(2-chloroethyl)(nitroso)carbamoyl]amino group. It is an organic phosphonate, a member of N-nitrosoureas and an organochlorine compound.
What are the applications of Application
Fotemustene is a nitrosourea alkylating agent
brand name
Muphoran
Properties of Fotemustine
| Melting point: | 85° |
| Density | 1.37±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | H2O: ≥1mg/mL |
| form | powder |
| pka | 9.47±0.46(Predicted) |
| color | light yellow |
| CAS DataBase Reference | 92118-27-9(CAS DataBase Reference) |
Safety information for Fotemustine
| Signal word | Warning |
| Pictogram(s) |
 Health Hazard GHS08 |
| GHS Hazard Statements |
H351:Carcinogenicity |
| Precautionary Statement Codes |
P281:Use personal protective equipment as required. |
Computed Descriptors for Fotemustine
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