Fotemustine

Synonym(s):(+-)-Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate;Muphoran;Mustophorane;P-[1-[[[(2-Chloroethyl)nitrosoamino]carbonyl]amino]ethyl]-phosphonic acid diethyl ester;S 10036

CAS NO.：92118-27-9
Empirical Formula: C9H19ClN3O5P
Molecular Weight: 315.69
MDL number: MFCD00866278
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 05:36:21

What is Fotemustine?

Description

Fotemustine is a new nitrosourea reportedly effective in the treatment of disseminated malignant melanoma, with only mild hematological toxicity. Response rate is generally lower in patients with colonic, breast, head and neck cancer.

Originator

Servier (France)

The Uses of Fotemustine

Fotemustine is used in patients malignant gliomas to improve the efficacy of radiotherapy. Used in the treatment of glioblastomas.

What are the applications of Application

Fotemustene is a nitrosourea alkylating agent

Definition

ChEBI: Diethyl (1-{[(2-chloroethyl)(nitroso)carbamoyl]amino}ethyl)phosphonate is a member of the class of N-nitrosoureas that is ethyl diethylphosphonate in the hydrogen at position 1 of the ethyl group attached to the phosphorus has been replaced by a [(2-chloroethyl)(nitroso)carbamoyl]amino group. It is an organic phosphonate, a member of N-nitrosoureas and an organochlorine compound.

brand name

Muphoran

Properties of Fotemustine

Melting point:	85°
Density	1.37±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	H2O: ≥1mg/mL
form	powder
pka	9.47±0.46(Predicted)
color	light yellow
CAS DataBase Reference	92118-27-9(CAS DataBase Reference)

Safety information for Fotemustine

Signal word	Warning
Pictogram(s)	Health Hazard GHS08
GHS Hazard Statements	H351:Carcinogenicity
Precautionary Statement Codes	P281:Use personal protective equipment as required.