Fmoc-NH-PEG12-CH2CH2COOH

CAS NO.：1952360-91-6
Empirical Formula: C42H65NO16
Molecular Weight: 839.96
Update Date: 2026-07-07 15:51:58

What is Fmoc-NH-PEG12-CH2CH2COOH?

Description

Fmoc-N-amido-PEG12-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

General Description

FmocNH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker. Fmoc-NH-PEG12-CH2CH2COOH can be used in the synthesis of PROTAC.

Storage

Keep in dark place,Inert atmosphere,Store in freezer, under -20 ℃.

Properties of Fmoc-NH-PEG12-CH2CH2COOH

Boiling point:	870.4±65.0 °C(Predicted)
Density	1.175±0.06 g/cm3(Predicted)
form	clear liquid
pka	4.28±0.10(Predicted)
color	Colorless to Light yellow

Safety information for Fmoc-NH-PEG12-CH2CH2COOH

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for Fmoc-NH-PEG12-CH2CH2COOH

InChIKey	JYNHRDJTWNEGJE-UHFFFAOYSA-N
SMILES	C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O

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