Fmoc-Trp(Boc)-OH
Synonym(s):Nα-Fmoc-N(in)-Boc-L -tryptophan;N(in)-Boc-Nα-Fmoc-L -tryptophan;Fmoc-Trp(Boc)-OH;N-α-Fmoc-N-in-t.-Boc-L-tryptophan
- CAS NO.：143824-78-6
- Empirical Formula: C31H30N2O6
- Molecular Weight: 526.58
- MDL number: MFCD00153366
- EINECS: 604-383-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:58:24
What is Fmoc-Trp(Boc)-OH?
Chemical properties
White solid
The Uses of Fmoc-Trp(Boc)-OH
Fmoc-Trp(Boc)-OH is a very useful synthetic intermediate. It is used to prepare Trp containing-peptides.
The Uses of Fmoc-Trp(Boc)-OH
Fmoc-Trp(Boc)-OH can be used for the synthesis of analogs of glucagon-like peptide-1 (GLP-1) for the treatment of type 2 diabetes and various peptides by Fmoc solid phase peptide synthesis (SPPS).
General Description
The use of this N-in-Boc protected derivative overcomes most of the problems associated with the preparation of Trp containing-peptides by Fmoc SPPS [1]. Cleavage with TFA generates an N-in-carboxy indole which protects the Trp from alkylation [1, 2, 3] and sulfonation [1, 4, 5, 6, 7]. The N-in-carboxy group is removed under aqueous conditions during normal work-up of the peptide.
The product number for this product was previously 04-12-1103.
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Properties of Fmoc-Trp(Boc)-OH
| Melting point: | ca 97℃ |
| alpha | -21 º (c=1%, DMF) |
| Density | 1.28±0.1 g/cm3(Predicted) |
| refractive index | -20 ° (C=1, DMF) |
| storage temp. | 2-8°C |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Solid |
| pka | 3.71±0.10(Predicted) |
| color | White to Orange to Green |
| optical activity | [α]20/D 21±2°, c = 1% in DMF |
| Sensitive | Moisture Sensitive |
| BRN | 7698009 |
| CAS DataBase Reference | 143824-78-6(CAS DataBase Reference) |
Safety information for Fmoc-Trp(Boc)-OH
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H317:Sensitisation, Skin H401:Hazardous to the aquatic environment, acute hazard H411:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P321:Specific treatment (see … on this label). P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. |
Computed Descriptors for Fmoc-Trp(Boc)-OH
| InChIKey | ADOHASQZJSJZBT-SANMLTNESA-N |
Fmoc-Trp(Boc)-OH manufacturer
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