FMoc-N-Me-Cys(Trt)-OH

Synonym(s):Fmoc-N-Me-Cys(Trt)-OH;N-α-Fmoc-N-α-methyl-S-trityl-L-cysteine

CAS NO.：944797-51-7
Empirical Formula: C38H33NO4S
Molecular Weight: 599.74
MDL number: MFCD11973909
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:58:24

What is FMoc-N-Me-Cys(Trt)-OH?

The Uses of FMoc-N-Me-Cys(Trt)-OH

Fmoc-N-Me-L-Cys(Trt)-OH (CAS# 944797-51-7) is an fmoc- and trityl-protected derivative of L-cysteine (C995000) used as a building block for peptides or peptide fragments, such as the solid-phase synthesis of Triostin A.

The Uses of FMoc-N-Me-Cys(Trt)-OH

Fmoc-N-Me-Cys(Trt)-OH is a Fmoc-protected derivative of N-methyl cysteine used as a building block to prepare peptide thioesters under acidic conditions. The residue attached to the amino group of N-methylcysteine can migrate to the cysteinyl thiol group, resulting in the formation of a peptide thioester. The introduction of this Fmoc-protected derivative is best achieved using HATU as a coupling reagent in the presence of DIPEA (N, N-Diisopropylethylamine).
It can also be used to prepare Fmoc-N-Me-Cys(Trt)-OAllyl intermediate for the solid-phase synthesis of dithiol Triostin A.

Properties of FMoc-N-Me-Cys(Trt)-OH

Melting point:	234-239°C
Boiling point:	746.0±60.0 °C(Predicted)
Density	1.260±0.06 g/cm3(Predicted)
storage temp.	Store at -15°C to -25°C.
form	Solid
pka	3.72±0.10(Predicted)
color	White to off-white
optical activity	[α]22/D -25.0°, c = 0.5% in dichloromethane