Flufenoxuron

Synonym(s):N-{4-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-fluorophenylaminocarbonyl}-2,6-difluoro-benzamide

CAS NO.：101463-69-8
Empirical Formula: C21H11ClF6N2O3
Molecular Weight: 488.77
MDL number: MFCD00274597
EINECS: 417-680-3
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:14:11

What is Flufenoxuron?

The Uses of Flufenoxuron

Flufenoxuron is an known insecticide and acts as an insect growth regulator by inhibiting chitin synthesis.

The Uses of Flufenoxuron

Flufenoxuron is used for the control of many phytophagous mites (Aculus, Brevipalpus, Pananychus, Phyllocoptuuta, Tetuanychus, spp) and insect pests on pome fruit, vines, citrus, tea, cotton, maize, vegetables and ornamentals. It is also used as a public hygiene insecticide.

Definition

ChEBI: Flufenoxuron is a benzoylurea insecticide, a member of monochlorobenzenes, a member of (trifluoromethyl)benzenes, a member of monofluorobenzenes and a difluorobenzene. It has a role as a mite growth regulator. It derives from a diphenyl ether.

Metabolic pathway

Information on the metabolism of flufenoxuron is avilable in a Pesticides Safety Directorate review of its use as a public hygiene insecticide (PSD).

Degradation

The DT₅₀ of flufenoxuron (25 °C) was 267 days at pH 7,206 days at pH 5 and 36.7 days at pH 9 (PM).
Flufenoxuron underwent photodegradation to form 2,6-difluorobenzamide (2), the urea derivative 3 and the 4-aminodiphenyl ether 4 in aqueous solution under natural sunlight in the UK (PSD, 1995).

Mode of action

Flufenoxuron acts in a similar manner to diflubenzuron, reducing chitin incorporation in the cuticJe (Clarke and Jewess 1990). It has cuticular and stomach action. It has ovo-Iarvicidal activity. Treated adults lay non-viable eggs (Tomlin 1995).

Properties of Flufenoxuron

Melting point:	169-172° (dec)
Density	1.5123 (estimate)
vapor pressure	6.52 x l0^-12 Pa (20 °C)
storage temp.	0-6°C
solubility	Benzene (Slightly, Heated), DMSO (Slightly), Ethyl Acetate (Sparingly)
form	neat
Water Solubility	4 x l0^-6 mg l^-1(25 °C)
pka	8.68±0.46(Predicted)
form	Solid
color	Off-White to Light Beige
BRN	8398323
CAS DataBase Reference	101463-69-8(CAS DataBase Reference)
EPA Substance Registry System	Flufenoxuron (101463-69-8)

Safety information for Flufenoxuron

Signal word	Warning
Pictogram(s)	Environment GHS09
GHS Hazard Statements	H362:Reproductive toxicity, effects on or via lactation H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P263:Avoid contact during pregnancy/while nursing. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P308+P313:IF exposed or concerned: Get medical advice/attention.