FG 2216

Synonym(s):[[(1-Chloro-4-hydroxyisoquinolin-3-yl)carbonyl]amino]acetic acid;IOX 3;N-[(1-Chloro-4-hydroxy-3-isoquinolinyl)carbonyl]glycine;

CAS NO.：223387-75-5
Empirical Formula: C12H9ClN2O4
Molecular Weight: 280.66
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-29 14:06:09

What is FG 2216?

Description

FG-2216 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2; IC₅₀ = 3.9 micromolar). It has been shown to reversibly stimulate erythropoietin secretion at 100 μM in vitro and to increase hematocrit, red blood cell count, and hemoglobin levels at 50 mg/kg in mice.

The Uses of FG 2216

FG 2216 is an erythropoietic agent which is orally active prolyl-hydroxylase inhibitor which increases erythropoietin production in end-stage kidney disease.

Biochem/physiol Actions

BIQ (FG-2216) is an orally available and potent inhibitor of prolyl-hydroxylase (PHD). BIQ induces significant and reversible plasma erythropoietin (EPO) levels in vitro and in hemodialysis patients.

References

1. hsieh mm, linde ns, wynter a et al. hif prolyl hydroxylase inhibitionresults in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. blood. 2007 sep 15;110(6):2140-7.

Properties of FG 2216

Boiling point:	670.6±55.0 °C(Predicted)
Density	1.571±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	insoluble in H2O; ≥14.05 mg/mL in DMSO; ≥5.12 mg/mL in EtOH with ultrasonic
pka	3.20±0.10(Predicted)
form	powder
color	white to beige

Safety information for FG 2216

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for FG 2216

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