FFAR2 (GPR43) (Internal) Polyclonal Antibody

Description

GPR43 is a G protein-coupled receptor activated by short chain fatty acids (SCFAs). Several SCFAs have the potential to bind and activate GPR43, including acetate, formate, propionate, and butyrate. GPR43 couples through the Pertussis toxin-sensitive G_i/o and the pertussis toxin-insensitive G_q protein families and its expression has been described in enteroendocrine cells and neutrophils. The activation of GPR43 induces an increase in intracellular Ca²⁺, ERK1/2 activation, and a decrease in intracellular cAMP. Activation of GPR43 may be involved in intestinal inflammation. The predicted size of GPR43 is 37 kDa. Cayman’s GPR43 (Internal) Polyclonal Antibody detects a 37 kDa band in cell lysates.