Fexofenadine hydrochloride
Synonym(s):Fexofenidine hydrochloride;MDL 16455 hydrochloride;Terfenidine carboxylate hydrochloride
- CAS NO.：153439-40-8
- Empirical Formula: C32H40ClNO4
- Molecular Weight: 538.13
- MDL number: MFCD08064193
- EINECS: 604-906-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-30 16:33:02
What is Fexofenadine hydrochloride ?
Description
Fexofenadine is a histamine H1 receptor antagonist (Ki = 10 nM). It reverses contraction of isolated rat tracheal strips induced by acetyl-β-methylcholine . Fexofenadine inhibits expression of IL-8 in TNF-α-stimulated HCT116 and COLO 205 cells. Oral administration of fexofenadine (2 and 10 mg/kg) reduces severity of colitis and phospho-IκB kinase activation in a mouse model of colitis induced by dextran sulfate sodium (DSS; ).
The Uses of Fexofenadine hydrochloride
Fexofenadine hydrochloride is used as an antihistamine that inhibits Cox-1, Cox-2, and is a histamine H1 receptor agonist.
What are the applications of Application
Fexofenadine HCl is an antihistamine that inhibits Cox-1, Cox-2, and is a histamine H1 receptor agonist
Properties of Fexofenadine hydrochloride
| Melting point: | 148-150oC |
| storage temp. | 2-8°C |
| solubility | Soluble in Dimethyl sulfoxide (50 mM), and methanol. |
| form | powder |
| color | white to beige |
Safety information for Fexofenadine hydrochloride
Computed Descriptors for Fexofenadine hydrochloride
| InChIKey | RRJFVPUCXDGFJB-UHFFFAOYSA-N |
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