fenproporex

Originator

Fenproporex,Chephasaar,W. Germany,1975

Definition

ChEBI: Fenproporex is a member of amphetamines.

Manufacturing Process

(a) 22 g of acrylonitrile and 27 g of racemic α-methyl-β-phenylethylamine were introduced into a 100 ml round-bottomed flask and left standing for 13 hours at ambient temperature, and then the mixture was boiled under reflux for 12? hours. The excess acrylonitrile was then evaporated in vacuo and the residue distilled. 27.3 g (yield: 72.6%) of racemic N-(β-cyanoethyl)-α-methyl- β-phenylethylamine were obtained as an oily liquid, BP = 126°C to 127°C/2 mm Hg.
(b) 22 g of the base obtained in (a) were dissolved in 80 ml of anhydrous diethyl ether and an ethereal solution of hydrochloric acid added until the pH value was 1. The salt was filtered off, dried and washed with 10 ml of diethyl ether. 18 g (yield: 68%) of N-(β-cyanoethyl-α-methyl-β-phenylethylamine hydrochloride were obtained, after recrystallization from absolute ethanol, as a white, microcrystalline, odorless powder having a bitter, acid taste; it was fairly soluble in water, ether and benzene. MP = 146°C on a Kofler block.

Therapeutic Function

Anorexic